THE SMART TRICK OF RAS-IN-2 THAT NO ONE IS DISCUSSING

Even though ectopic activation of mTORC1 in peripheral tissues might be accomplished by administering a large dose of exogenous leucine, mTORC1 signaling in the CNS remains refractory most likely due to the rapid turnover and buffering of leucine inside the brain18,19. The discovery of Sestrin1 and 2 as a certain leucine sensor upstream of mTORC1 d